Infiltration of polarized macrophages associated with liver fibrosis in infants with biliary atresia.

doi:10.1016/j.jpedsurg.2017.08.045

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Article

Infiltration of polarized macrophages associated with liver fibrosis in infants with biliary atresia.

Journal of pediatric surgery - 1 Dec 2017

Yang Yifan, Dong Rui, Zheng Chao, Zheng Shan, Chen Gong

Abstract excerpt

BACKGROUND/PURPOSE: Macrophages exert critical functions in liver homeostasis and have been proposed as potential targets in combatting fibrosis. We aimed to evaluate polarized functional status of liver infiltrated macrophages in infants with biliary atresia (BA). METHODS: Immunohistochemical staining for CD68, CD163, and IRF5 was performed in 40 BA infants. Liver biopsies were scored for fibrosis and tested for...

Topics

Antigens, CD
Antigens, Differentiation, Myelomonocytic
Biliary Atresia
Female
Humans
Infant
Liver Cirrhosis
Liver Function Tests
Macrophages
Male
Phenotype
Receptors, Cell Surface
CD163 Antigen

Source

Open in PubMed

Identifiers

PMID: 28927974
DOI: 10.1016/j.jpedsurg.2017.08.045

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