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Article

Host genetic background impacts modulation of the TLR4 pathway by RON in tissue-associated macrophages.

Immunology and cell biology - 1 Aug 2013

Chaudhuri Amitabha, Wilson Nicholas S, Yang Becky, Paler Martinez Andres, Liu Jinfeng, Zhu Catherine, Bricker Nicole, Couto Suzana, Modrusan Zora, French Dorothy, Cupp James, Ashkenazi Avi

Abstract excerpt

Toll-like receptors (TLRs) enable metazoans to mount effective innate immune responses to microbial and viral pathogens, as well as to endogenous host-derived ligands. It is understood that genetic background of the host can influence TLR responsiveness, altering susceptibility to pathogen infection, autoimmunity and cancer. Macrophage stimulatory protein (MSP), which activates the receptor tyrosine kinase...

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Identifiers

PMID: 23817579
DOI: 10.1038/icb.2013.27
PMCID: PMC3736205

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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