Article
Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis.
Biochimica et biophysica acta. Molecular basis of disease - 1 May 2021
Kotlinowski Jerzy, Hutsch Tomasz, Czyzynska-Cichon Izabela, Wadowska Marta, Pydyn Natalia, Jasztal Agnieszka, Kij Agnieszka, Dobosz Ewelina, Lech Maciej, Miekus Katarzyna, Pośpiech Ewelina, Fu Mingui, Jura Jolanta, Koziel Joanna, Chlopicki Stefan
Abstract excerpt
Primary biliary cholangitis (PBC) is an autoimmune disease characterized by progressive destruction of the intrahepatic bile ducts. The immunopathology of PBC involves excessive inflammation; therefore, negative regulators of inflammatory response, such as Monocyte Chemoattractant Protein-1-Induced Protein-1 (MCPIP1) may play important roles in the development of PBC. The aim of this work was to verify whether...
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