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Article

Tissue-Resident Macrophages Promote Renal Cystic Disease.

Journal of the American Society of Nephrology : JASN - 1 Oct 2019

Zimmerman Kurt A, Song Cheng J, Li Zhang, Lever Jeremie M, Crossman David K, Rains Addison, Aloria Ernald J, Gonzalez Nancy M, Bassler John R, Zhou Juling, Crowley Michael R, Revell Dustin Z, Yan Zhaoqi, Shan Dan, Benveniste Etty N, George James F, Mrug Michal, Yoder Bradley K

Abstract excerpt

BACKGROUND: Mutations affecting cilia proteins have an established role in renal cyst formation. In mice, the rate of cystogenesis is influenced by the age at which cilia dysfunction occurs and whether the kidney has been injured. Disruption of cilia function before postnatal day 12-14 results in rapid cyst formation; however, cyst formation is slower when cilia dysfunction is induced after postnatal day 14....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Diseases, Cystic

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Source

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Identifiers

PMID: 31337691
DOI: 10.1681/ASN.2018080810
PMCID: PMC6779366

Genes

CSF1
CSF1R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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