Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ers1 links HP1 to RNAi.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2012

Rougemaille Mathieu, Braun Sigurd, Coyle Scott, Dumesic Phillip A, Garcia Jennifer F, Isaac Richard Stefan, Libri Domenico, Narlikar Geeta J, Madhani Hiten D

Abstract excerpt

Pericentromeric heterochromatin formation is mediated by repressive histone H3 lysine 9 methylation (H3K9Me) and its recognition by HP1 proteins. Intriguingly, in many organisms, RNAi is coupled to this process through poorly understood mechanisms. In Schizosaccharomyces pombe, the H3-K9 methyltransferase Clr4 and the heterochromatin protein 1 (HP1) ortholog Swi6 are critical for RNAi, whereas RNAi stimulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromobox Protein Homolog 5
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoribonucleases

Share to Gene Silencing

Share to Heterochromatin

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Two-Hybrid System Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 22733737
DOI: 10.1073/pnas.1204947109
PMCID: PMC3396509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ers1 links HP1 to RNAi.PMID 22733737Read ↗

Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.Semantic proximity Read ↗

Analysis of a Rpb2 mutant in <i>Schizosaccharomyces pombe</i> reveals a non-canonical role for Elp1 in regulating RNAi-dependent heterochromatin assemblySemantic proximity Read ↗

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.Semantic proximity Read ↗

RNAi-mediated targeting of heterochromatin by the RITS complex.Semantic proximity Read ↗

CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing.Semantic proximity Read ↗

Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.Semantic proximity Read ↗

Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.Semantic proximity Read ↗

An enhancer screen identifies new suppressors of small-RNA-mediated epigenetic gene silencing.Semantic proximity Read ↗

Deletion of Elongator Protein 1 (Elp1) relieves heterochromatin defects in a Pol II mutant of Schizosaccharomyces pombe.Semantic proximity Read ↗

Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly.Semantic proximity Read ↗

A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe.Semantic proximity Read ↗

An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.