Article

siRNAs targeting a chromatin-associated RNA induce its transcriptional silencing in human cells

2022-05-11

Abstract excerpt

Transcriptional gene silencing by small interfering RNAs (siRNAs) has been widely described in various species, such as plants or fission yeasts. In mammals, its extent remained somewhat debated. Previous studies showed that siRNAs targeting gene promoters can induce the silencing of the targeted promoter, although the involvement of off-target mechanisms was also suggested. Here, by nascent RNA capture and RNA Po...

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Literature Corpus work: 7dd81e0f-ec6b-5e03-b7b3-d79008d5ae74
DOI: 10.1101/2022.05.11.491477

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