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Article

Deposition of Phosphorylated α-Synuclein and Activation of GSK-3β and PP2A in the PS19 Mouse Model of Tauopathy.

Journal of neuropathology and experimental neurology - 10 Sept 2021

Takaichi Yuta, Chambers James K, Ano Yasuhisa, Takashima Akihiko, Nakayama Hiroyuki, Uchida Kazuyuki

Abstract excerpt

The simultaneous accumulation of multiple pathological proteins, such as hyperphosphorylated tau (hp-tau) and phosphorylated α-synuclein (p-αSyn), has been reported in the brains of patients with various neurodegenerative diseases. We previously demonstrated that hp-tau-dependent p-αSyn accumulation was associated with the activation of GSK-3β in the brains of P301L tau transgenic mice. To confirm the effects of...

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PMID: 34151989
DOI: 10.1093/jnen/nlab054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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