Article
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
Experimental neurology - 1 Apr 2005
Frasier M, Walzer M, McCarthy L, Magnuson D, Lee J M, Haas C, Kahle P, Wolozin B
Abstract excerpt
Mice overexpressing mutant alpha-synuclein develop a progressive loss of motor function associated with the accumulation of aggregated alpha-synuclein in neurons of the brainstem. Recent reports suggest that tau pathology might also be associated with Parkinson disease (PD) and aggregation of alpha-synuclein. We now report that mice overexpressing A30P alpha-synuclein develop abnormally phosphorylated tau in...
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