Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PKCε controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode.

International journal of biological macromolecules - 31 Aug 2021

Serrano-López Emilio M, López-Martínez David, Gómez-Fernández Juan C, Egea-Jiménez Antonio Luis, Corbalán-García Senena

Abstract excerpt

PKCε is highly expressed in mast cells and plays a fundamental role in the antigen-triggered activation of the allergic reaction. Although its regulation by diacylglycerols has been described, its regulation by acidic phospholipids and how this regulation leads to the control of downstream vesicle secretion is barely known. Here, we used structural and evolutionary studies to find the molecular mechanism that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Cell Fusion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mast Cells

Share to Phosphatidic Acids

Share to Protein Kinase C-epsilon

Share to Secretory Vesicles

Share to SNARE Proteins

Share to Vesicular Transport Proteins

Source

Identifiers

PMID: 34147527
DOI: 10.1016/j.ijbiomac.2021.06.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PKCε controls the fusion of secretory vesicles in mast cells in a phosphatidic acid-dependent mode.PMID 34147527Read ↗

The simultaneous production of phosphatidic acid and diacylglycerol is essential for the translocation of protein kinase Cepsilon to the plasma membrane in RBL-2H3 cells.Semantic proximity Read ↗

The C2 domain of PKCalpha is a Ca2+ -dependent PtdIns(4,5)P2 sensing domain: a new insight into an old pathway.Semantic proximity Read ↗

C2 Domains of Munc13-4 Are Crucial for Ca2+-Dependent Degranulation and Cytotoxicity in NK Cells.Semantic proximity Read ↗

Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer.Semantic proximity Read ↗

Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface.Semantic proximity Read ↗

TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity.Semantic proximity Read ↗

The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells.Semantic proximity Read ↗

Membrane association domains in Ca2+-dependent activator protein for secretion mediate plasma membrane and dense-core vesicle binding required for Ca2+-dependent exocytosis.Semantic proximity Read ↗

Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC.Semantic proximity Read ↗

The origin of C1A-C2 interdomain interactions in protein kinase Calpha.Semantic proximity Read ↗

Rab46: a novel player in mast cell functionSemantic proximity Read ↗

Protein kinase C theta (PKCtheta): a key player in T cell life and death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.