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Article

Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2005

Seki Takahiro, Matsubayashi Hiroaki, Amano Taku, Shirai Yasuhito, Saito Naoaki, Sakai Norio

Abstract excerpt

Protein kinase C (PKC) is translocated to various cellular regions in a subtype and stimulation-dependent manner. Thereafter, the activated PKC phosphorylates its substrate and causes subsequent cellular responses (PKC targeting). The 3-phosphoinositide-dependent protein kinase-1 (PDK1) has an essential role in the maturation of PKC by phosphorylating a threonine residue in the PKC activation loop. To elucidate...

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Identifiers

PMID: 15743412
DOI: 10.1111/j.1365-2443.2005.00830.x

Genes

PDK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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