Article
C2 Domains of Munc13-4 Are Crucial for Ca2+-Dependent Degranulation and Cytotoxicity in NK Cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2018
Bin Na-Ryum, Ma Ke, Tien Chi-Wei, Wang Siyan, Zhu Dan, Park Seungmee, Turlova Ekaterina, Sugita Kyoko, Shirakawa Ryutaro, van der Sluijs Peter, Horiuchi Hisanori, Sun Hong-Shuo, Monnier Philippe P, Gaisano Herbert Y, Sugita Shuzo
Abstract excerpt
In the immune system, degranulation/exocytosis from lymphocytes is crucial for life through facilitating eradication of infected and malignant cells. Dysfunction of the NK cell exocytosis process has been implicated with devastating immune diseases, such as familial hemophagocytic lymphohistiocytosis, yet the underlying molecular mechanisms of such processes have remained elusive. In particular, although the...
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