Article
The simultaneous production of phosphatidic acid and diacylglycerol is essential for the translocation of protein kinase Cepsilon to the plasma membrane in RBL-2H3 cells.
Molecular biology of the cell - 1 Dec 2003
Jose Lopez-Andreo Maria, Gomez-Fernandez Juan C, Corbalan-Garcia Senena
Abstract excerpt
To evaluate the role of the C2 domain in protein kinase Cepsilon (PKCepsilon) localization and activation after stimulation of the IgE receptor in RBL-2H3 cells, we used a series of mutants located in the phospholipid binding region of the enzyme. The results obtained suggest that the interaction...
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