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Article

The C2 domain of PKCalpha is a Ca2+ -dependent PtdIns(4,5)P2 sensing domain: a new insight into an old pathway.

Journal of molecular biology - 6 Oct 2006

Sánchez-Bautista Sonia, Marín-Vicente Consuelo, Gómez-Fernández Juan C, Corbalán-García Senena

Abstract excerpt

The C2 domain is a targeting domain that responds to intracellular Ca2+ signals in classical protein kinases (PKCs) and mediates the translocation of its host protein to membranes. Recent studies have revealed a new motif in the C2 domain, named the lysine-rich cluster, that interacts with acidic phospholipids. The purpose of this work was to characterize the molecular mechanism by which PtdIns(4,5)P2...

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Source

Identifiers

PMID: 16949603
DOI: 10.1016/j.jmb.2006.07.093

Genes

CFP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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