Article
The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells.
Science signaling - 10 Sept 2013
Kim Do Kyun, Kim Hyuk Soon, Kim A-Ram, Jang Geun Hyo, Kim Hyun Woo, Park Young Hwan, Kim Bokyung, Park Yeong Min, Beaven Michael A, Kim Young Mi, Choi Wahn Soo
Abstract excerpt
The protein prohibitin (PHB) is implicated in diverse cellular processes, including cell signaling, transcriptional control, and mitochondrial function. We found that PHB was abundant in the intracellular granules of mast cells, which are critical for allergic responses to antigens. Thus, we investigated whether PHB played a role in signaling mediated by the high-affinity receptor for antigen-bound immunoglobulin...
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