Article
Membrane association domains in Ca2+-dependent activator protein for secretion mediate plasma membrane and dense-core vesicle binding required for Ca2+-dependent exocytosis.
The Journal of biological chemistry - 14 Jun 2002
Grishanin Ruslan N, Klenchin Vadim A, Loyet Kelly M, Kowalchyk Judith A, Ann Kyoungsook, Martin Thomas F J
Abstract excerpt
Ca2+-dependent activator protein for secretion (CAPS) is a cytosolic protein essential for the Ca2+-dependent fusion of dense-core vesicles (DCVs) with the plasma membrane and the regulated secretion of a subset of neurotransmitters. The mechanism by which CAPS functions in exocytosis and the means by which it associates with target membranes are unknown. We identified two domains in CAPS with distinct...
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