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Article

Mapping pleiotropic loci using a fast-sequential testing algorithm.

European journal of human genetics : EJHG - 1 Dec 2021

Aguate Fernando M, Vazquez Ana I, Merriman Tony R, de Los Campos Gustavo

Abstract excerpt

Pleiotropy (i.e., genes with effects on multiple traits) leads to genetic correlations between traits and contributes to the development of many syndromes. Identifying variants with pleiotropic effects on multiple health-related traits can improve the biological understanding of gene action and disease etiology, and can help to advance disease-risk prediction. Sequential testing is a powerful approach for mapping...

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Source

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Identifiers

PMID: 34145383
DOI: 10.1038/s41431-021-00911-z
PMCID: PMC8633382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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