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Article

multi-GPA-Tree: Statistical approach for pleiotropy informed and functional annotation tree guided prioritization of GWAS results.

PLoS computational biology - 1 Dec 2023

Khatiwada Aastha, Yilmaz Ayse Selen, Wolf Bethany J, Pietrzak Maciej, Chung Dongjun

Abstract excerpt

Genome-wide association studies (GWAS) have successfully identified over two hundred thousand genotype-trait associations. Yet some challenges remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), most with small or moderate effect sizes, making them difficult to detect. Second, many complex traits share a common genetic basis due to 'pleiotropy' and and though few...

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PMID: 38060592
DOI: 10.1371/journal.pcbi.1011686
PMCID: PMC10729974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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