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AXL receptor tyrosine kinase: a possible therapeutic target in acute promyelocytic leukemia

17 Jun 2021

Abstract excerpt

BACKGROUND: Acute promyelocytic leukemia (APL) is a subset of acute myeloid leukemia (AML) which is characterized by the fusion of promyelocytic leukemia PML and retinoic acid receptor- alpha (RAR-alpha) genes. All-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO) have resulted in durable cytogenetic and molecular remissions in most APL patients and have altered the natural history of the disease. Most APL...

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Share to Chronic Myeloid Leukemia Treatments
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PMID: 34140003
DOI: 10.1186/s12885-021-08450-y

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