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Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer

9 Jun 2015

Abstract excerpt

Acute promyelocytic leukaemia (APL), the M3 subtype of acute myeloid leukaemia, was once a lethal disease, yet nowadays the majority of patients with APL can be successfully cured by molecularly targeted therapy. This dramatic improvement in the survival rate is an example of the advantage of modern medicine. APL is characterized by a balanced reciprocal chromosomal translocation fusing the promyelocytic...

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PMID: 26058416
DOI: 10.1111/joim.12376

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