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Article

The success and the challenge of all-trans retinoic acid in the treatment of cancer

2 Oct 2018

Abstract excerpt

All-trans retinoic acid (ATRA), an active metabolite of vitamin A, plays important roles in cell proliferation, cell differentiation, apoptosis, and embryonic development. The effects of ATRA are mediated by nuclear retinoid receptors as well as non-genomic signal pathway, such as MAPK and PKA. The great success of differentiation therapy with ATRA in acute promyelocytic leukemia (APL) not only improved the...

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Identifiers

PMID: 30277803
DOI: 10.1080/10408398.2018.1509201

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