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Article

Unlocking the potential of retinoic acid in anticancer therapy

1 Nov 2014

Abstract excerpt

All-trans-retinoic acid (ATRA) is a physiologically active metabolite of vitamin A. Its antitumour activities have been extensively studied in a variety of model systems and clinical trials; however, to date the only malignancy responsive to ATRA treatment is acute promyelocytic leukaemia (APL) where it induces complete remission in the majority of cases when administered in combination with light chemotherapy...

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PMID: 25412233
DOI: 10.1038/bjc.2014.412

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