Article

ATRA Resistance in Acute Promyelocytic Leukemia: Mechanisms Unveiled, Therapies Reimagined

2025-06-30

Abstract excerpt

All-trans retinoic acid (ATRA) has dramatically improved outcomes for patients with acute promyelocytic leukemia (APL), turning a once fatal disease into one that is often curable. Yet, resistance to ATRA remains a significant challenge, especially in relapsed cases. This review outlines key mechanisms contributing to resistance, including mutations in the RARA ligand-binding domain, disruption of promyelocytic le...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2dba00ec-e18c-5054-8804-eefa5ea15e10
DOI: 10.20944/preprints202506.2519.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ATRA Resistance in Acute Promyelocytic Leukemia: Mechanisms Unveiled, Therapies ReimaginedDOI 10.20944/preprints202506.2519.v1Read

Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment StrategiesSemantic proximity Read

Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment StrategiesSemantic proximity Read

ATRA(ouble) in the treatment of acute promyelocytic leukemia.Semantic proximity Read

Acute promyelocytic leukemia: from highly fatal to highly curableSemantic proximity Read

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemiaSemantic proximity Read

Unlocking the potential of retinoic acid in anticancer therapySemantic proximity Read

Recent advances in acute promyelocytic leukaemiaSemantic proximity Read

Acute promyelocytic leukemia (APL): a review of the literatureSemantic proximity Read

Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experienceSemantic proximity Read

Retinoic acid resistance in acute promyelocytic leukemiaSemantic proximity Read

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemiaSemantic proximity Read

Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapiesSemantic proximity Read