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T cell exhaustion initiates tertiary lymphoid structures and turbocharges cancer-immunity cycle

14 May 2024

Abstract excerpt

Immune therapies represented by immune checkpoint blockade (ICB) have significantly transformed cancer treatment. However, the effectiveness of these treatments depends on the status of T cells. T cell exhaustion, characterized by diminished effector function, increased expression of co-inhibitory receptors, and clonal deletion, emerges as a hypofunctional state resulting from chronic exposure to antigens, posing...

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PMID: 38749300
DOI: 10.1016/j.ebiom.2024.105154

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