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T-cell exhaustion in tuberculosis: pitfalls and prospects

1 Nov 2016

Abstract excerpt

T-cells play an important role in immunity but when these cells are overexposed to specific antigens, their function may decline. This state is usually referred to as exhaustion and the T-cells show reduced proliferation and functions such as cytokine release. T-cell exhaustion has been observed in several cancers as well as in chronic infections such as tuberculosis (TB). In chronic Mycobacterium tuberculosis...

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PMID: 27800700
DOI: 10.1080/1040841x.2016.1185603

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