Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2008

Macdonald Jennifer L, Pike Linda J

Abstract excerpt

Scatchard analysis of the binding of EGF to its receptor yields concave up plots that indicate the presence of two classes of binding sites. However, how two independent classes of sites arise from the expression of a single EGF receptor protein has never been adequately explained. Using a new analytical approach involving the simultaneous fitting of binding isotherms from cells expressing increasing levels of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemistry
Share to CHO Cells
Share to Cricetulus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dimerization

Share to Epidermal Growth Factor

Share to Ligands

Share to Models, Chemical

Share to Models, Theoretical

Source

Open in PubMed Open full text

Identifiers

PMID: 18165319
DOI: 10.1073/pnas.0707080105
PMCID: PMC2224169

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system.PMID 18165319Read ↗

Implications of epidermal growth factor (EGF) induced egf receptor aggregation.Semantic proximity Read ↗

Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling.Semantic proximity Read ↗

A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer?Semantic proximity Read ↗

Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.Semantic proximity Read ↗

EGF receptor activation: push comes to shove.Semantic proximity Read ↗

Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.Semantic proximity Read ↗

Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation.Semantic proximity Read ↗

An integrated mechanistic and data-driven computational model predicts cell responses to high- and low-affinity EGFR ligandsSemantic proximity Read ↗

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.Semantic proximity Read ↗

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.Semantic proximity Read ↗

Glioblastoma mutations impair ligand discrimination by EGFRSemantic proximity Read ↗

Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.