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Article

Structural basis of the effect of activating mutations on the EGF receptor.

eLife - 28 Jul 2021

Galdadas Ioannis, Carlino Luca, Ward Richard A, Hughes Samantha J, Haider Shozeb, Gervasio Francesco Luigi

Abstract excerpt

Mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are common oncogenic driver events in non-small cell lung cancer. Although the activation of EGFR in normal cells is primarily driven by growth-factor-binding-induced dimerization, mutations on different exons of the kinase domain of the receptor have been found to affect the equilibrium between its active and inactive conformations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34319231
DOI: 10.7554/eLife.65824
PMCID: PMC8318590

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