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Article

Sex Differences in the Immune System Become Evident in the Perinatal Period in the Four Core Genotypes Mouse.

Frontiers in endocrinology - 1 Jan 2021

Ghosh Mrinal K, Chen Kuan-Hui E, Dill-Garlow Riva, Ma Lisa J, Yonezawa Tomohiro, Itoh Yuichiro, Rivera Lorena, Radecki Kelly C, Wu Quiming P, Arnold Arthur P, Muller H Konrad, Walker Ameae M

Abstract excerpt

We have used the four core genotypes (FCG) mouse model, which allows a distinction between effects of gonadal secretions and chromosomal complement, to determine when sex differences in the immune system first appear and what influences their development. Using splenic T cell number as a measure that could be applied to neonates with as yet immature immune responses, we found no differences among the four...

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Identifiers

PMID: 34122327
DOI: 10.3389/fendo.2021.582614
PMCID: PMC8191418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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