Four Core Genotypes and XY* mouse models: Update on impact on SABV research.

doi:10.1016/j.neubiorev.2020.09.021

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Article

Four Core Genotypes and XY* mouse models: Update on impact on SABV research.

Neuroscience and biobehavioral reviews - 1 Dec 2020

Arnold Arthur P

Abstract excerpt

The impact of two mouse models is reviewed, the Four Core Genotypes and XY* models. The models are useful for determining if the causes of sex differences in phenotypes are either hormonal or sex chromosomal, or both. Used together, the models also can distinguish between the effects of X or Y chromosome genes that contribute to sex differences in phenotypes. To date, the models have been used to uncover sex...

Topics

Animals
Female
Genotype
Male
Mice
Phenotype
Sex Characteristics
Sex Chromosomes
X Chromosome

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Identifiers

PMID: 32980399
DOI: 10.1016/j.neubiorev.2020.09.021
PMCID: PMC7736196

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