Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Independent contribution of gonads and sex chromosomes to sex differences in bone mass and strength in the four-core genotypes mouse model.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 29 Oct 2024

Ramirez Gabriel, Okpara Chiebuka, Arnett Matthew, Segvich Dyann M, Deosthale Padmini, González Paola Ortiz, Kritikos Alexander E, Melo Julian Balanta, Sanz Natasha, Pin Fabrizio, Wallace Joseph M, Plotkin Lilian I

Abstract excerpt

Vertebrate sexual dimorphism is ascribed to the presence of testes or ovaries, and, hence, to the secretion of gonad-specific hormones. However, mounting evidence indicates that sex differences in tissues and organs also stem from the presence of sex chromosomes (XX or XY). To tease out the contribution of gonads from sex chromosomes to the musculoskeletal system, we used the Four-Core Genotypes (FCG) mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Density

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gonads

Share to Models, Animal

Share to Organ Size

Share to Sex Characteristics

Share to Sex Chromosomes

Share to Y Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 39255371
DOI: 10.1093/jbmr/zjae147
PMCID: PMC11523188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Independent contribution of gonads and sex chromosomes to sex differences in bone mass and strength in the four-core genotypes mouse model.PMID 39255371Read ↗

Sex chromosome and gonadal contributions to body composition and skeletal mass and strength in aged four core genotypes (FCG) mice.Semantic proximity Read ↗

Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues.Semantic proximity Read ↗

Four Core Genotypes Mice Exhibit Quantitative Differences in T and B Cell Subpopulations compared to Wild-type MiceSemantic proximity Read ↗

Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) on Bone Structure in Male and Female Mice: Insights from the Four Core Genotypes miceSemantic proximity Read ↗

The Number of X Chromosomes Causes Sex Differences in Adiposity in MiceSemantic proximity Read ↗

Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more.Semantic proximity Read ↗

Four core genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels.Semantic proximity Read ↗

The Sex Chromosome Trisomy mouse model of XXY and XYY: metabolism and motor performanceSemantic proximity Read ↗

Sexual Dimorphism in the Musculoskeletal System: Sex Hormones and BeyondSemantic proximity Read ↗

<i>Sry</i> -modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and moreSemantic proximity Read ↗

The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation.Semantic proximity Read ↗

Sex Differences in the Immune System Become Evident in the Perinatal Period in the Four Core Genotypes Mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.