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Article

The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation.

Biology of sex differences - 31 Oct 2024

Wiese Carrie B, Soliman Barbara, Reue Karen

Abstract excerpt

The Four Core Genotypes (FCG) mouse model has become a valuable model to study the mechanistic basis for biological sex differences. This model allows discrimination between influences of gonadal sex (ovaries or testes) from those associated with genetic sex (presence of XX or XY chromosome complement). FCG mice have illuminated distinct effects of gonadal and chromosomal sex on traits ranging from brain...

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Identifiers

PMID: 39482704
DOI: 10.1186/s13293-024-00665-5
PMCID: PMC11529163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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