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Sex chromosome and gonadal contributions to body composition and skeletal mass and strength in aged four core genotypes (FCG) mice.

Bone - 1 Apr 2026

Ortiz Gonzalez Paola, Teal Alix, Chellaganapathy Lakshmi, Ramirez Gabriel, Pianeta Roquelina, Segvich Dyann M, Liu Ziyue, Wallace Joseph M, Plotkin Lilian I

Abstract excerpt

Sex differences in musculoskeletal aging are often attributed to gonadal hormones, but the independent role of sex chromosomes remains unclear. Using the Four Core Genotype mouse model, which dissociates sex chromosomes (XX vs. XY) from gonadal sex (ovaries vs. testes), our goal was to examine sex chromosomes and gonads independent and interactive effects on bone, muscle and organ phenotypes from 8 to 20 months...

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Aging
Body Composition
Bone and Bones
Bone Density
Gonads

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sex Chromosomes

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Identifiers

PMID: 41520751
DOI: 10.1016/j.bone.2026.117785
PMCID: PMC12871534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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