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Article

What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues?

Frontiers in neuroendocrinology - 1 Jan 2009

Arnold Arthur P, Chen Xuqi

Abstract excerpt

The "four core genotypes" (FCG) model comprises mice in which sex chromosome complement (XX vs. XY) is unrelated to the animal's gonadal sex. The four genotypes are XX gonadal males or females, and XY gonadal males or females. The model allows one to measure (1) the differences in phenotypes caused by sex chromosome complement (XX vs. XY), (2) the differential effects of ovarian and testicular secretions, and (3)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19028515
DOI: 10.1016/j.yfrne.2008.11.001
PMCID: PMC3282561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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