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Article

Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.

Nature communications - 11 Oct 2024

Panten Jasper, Del Prete Stefania, Cleland James P, Saunders Lauren M, van Riet Job, Schneider Anja, Ginno Paul, Schneider Nina, Koch Marie-Luise, Chen Xuqi, Gerstung Moritz, Stegle Oliver, Arnold Arthur P, Turner James M A, Heard Edith, Odom Duncan T

Abstract excerpt

The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39394207
DOI: 10.1038/s41467-024-52640-8
PMCID: PMC11470063

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MB

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