Article
Four core genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels.
BMC research notes - 7 Mar 2015
Itoh Yuichiro, Mackie Ryan, Kampf Kathy, Domadia Shelly, Brown Judith D, O'Neill Rachel, Arnold Arthur P
Abstract excerpt
BACKGROUND: The "four core genotypes" (FCG) mouse model has emerged as a major model testing if sex differences in phenotypes are caused by sex chromosome complement (XX vs. XY) or gonadal hormones or both. The model involves deletion of the testis-determining gene Sry from the Y chromosome and insertion of an Sry transgene onto an autosome. It produces XX and XY mice with testes, and XX and XY mice with ovaries,...
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