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Minireview: PRKAR1A: Normal and Abnormal Functions

27 Aug 2004

Abstract excerpt

The type 1alpha regulatory subunit (RIalpha) of cAMP-dependent protein kinase (PKA) (coded by the PRKAR1A gene) is the main component of type I PKA, which regulates most of the serine-threonine kinase activity catalyzed by the PKA holoenzyme in response to cAMP. Carney complex (CNC), or the complex of spotty skin pigmentation, myxomas, and endocrine overactivity, is a multiple endocrine (and not only) neoplasia...

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PMID: 15331577
DOI: 10.1210/en.2004-0900

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