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Article

Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA).

PloS one - 1 Jan 2012

Søberg Kristoffer, Larsen Anja C V, Diskar Mandy, Backe Paul H, Bjørås Magnar, Jahnsen Tore, Laerdahl Jon K, Rognes Torbjørn, Herberg Friedrich W, Skålhegg Bjørn S

Abstract excerpt

The genes PRKACA and PRKACB encode the principal catalytic (C) subunits of protein kinase A (PKA) Cα and Cβ, respectively. Cα is expressed in all eukaryotic tissues examined and studies of Cα knockout mice demonstrate a crucial role for Cα in normal physiology. We have sequenced exon 2 through 10 of PRKACA from the genome of 498 Norwegian donors and extracted information about PRKACA mutations from public...

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Source

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Identifiers

PMID: 22514673
DOI: 10.1371/journal.pone.0034838
PMCID: PMC3325940

Genes

PRKACA
PRKACB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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