Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion.

doi:10.1172/JCI140073

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion.

The Journal of clinical investigation - 15 Jul 2021

Simmons Jason D, Van Phu T, Stein Catherine M, Chihota Violet, Ntshiqa Thobani, Maenetje Pholo, Peterson Glenna J, Reynolds Anthony, Benchek Penelope, Velen Kavindhran, Fielding Katherine L, Grant Alison D, Graustein Andrew D, Nguyen Felicia K, Seshadri Chetan, Gottardo Raphael, Mayanja-Kizza Harriet, Wallis Robert S, Churchyard Gavin, Boom W Henry, Hawn Thomas R

Abstract excerpt

After extensive exposure to Mycobacterium tuberculosis (Mtb), most individuals acquire latent Mtb infection (LTBI) defined by a positive tuberculin skin test (TST) or interferon-γ release assay (IGRA). To identify mechanisms of resistance to Mtb infection, we compared transcriptional profiles from highly exposed contacts who resist TST/IGRA conversion (resisters, RSTRs) and controls with LTBI using RNAseq. Gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PRKAG2 gene

Share to Latent Tuberculosis

Share to Monocytes

Share to Mycobacterium tuberculosis

Share to Polymorphism, Single Nucleotide

Share to Transcription, Genetic

Share to U937 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 34111032
DOI: 10.1172/JCI140073
PMCID: PMC8279582

Genes

TST
PRKAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monocyte metabolic transcriptional programs associate with resistance to tuberculin skin test/interferon-γ release assay conversion.PMID 34111032Read ↗

Epigenetic programming of host lipid metabolism associates with resistance to TST/IGRA conversion after exposure to <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

<i>Mycobacterium tuberculosis</i>-dependent Monocyte Expression Quantitative Trait Loci and Tuberculosis PathogenesisSemantic proximity Read ↗

Mycobacterium tuberculosis-dependent monocyte expression quantitative trait loci, cytokine production, and TB pathogenesisSemantic proximity Read ↗

Multi-omic latent variable data integration reveals multicellular structure pathways associated with resistance to tuberculin skin test (TST)/interferon gamma release assay (IGRA) conversion in UgandaSemantic proximity Read ↗

Differentially expressed transcript isoforms associate with resistance to tuberculin skin test and interferon gamma release assay conversion.Semantic proximity Read ↗

Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiringSemantic proximity Read ↗

Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responsesSemantic proximity Read ↗

Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype.Semantic proximity Read ↗

Circulating metabolites associated with protection against Mycobacterium tuberculosis infection and inhibition of mycobacterial growth.Semantic proximity Read ↗

Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human monocyte-derived macrophages and blunt glycolysis in response to antigenic stimuliSemantic proximity Read ↗

Circulating metabolites associated with protection against Mycobacterium tuberculosis infection and inhibition of mycobacterial growthSemantic proximity Read ↗

Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.