Multi-omic latent variable data integration reveals multicellular structure pathways associated with resistance to tuberculin skin test (TST)/interferon gamma release assay (IGRA) conversion in Uganda.

doi:10.1186/s12864-025-11407-1

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Multi-omic latent variable data integration reveals multicellular structure pathways associated with resistance to tuberculin skin test (TST)/interferon gamma release assay (IGRA) conversion in Uganda.

BMC genomics - 18 Mar 2025

Cox Madison S, Dill-McFarland Kimberly A, Simmons Jason D, Benchek Penelope, Mayanja-Kizza Harriet, Boom W Henry, Stein Catherine M, Hawn Thomas R

Abstract excerpt

Understanding the mechanisms of early clearance of Mycobacterium tuberculosis (Mtb) may illuminate new therapeutic strategies for tuberculosis (TB). We previously found genetic, epigenetic, and transcriptomic signatures associated with resistance (resister, RSTR) to tuberculin skin test (TST)/interferon gamma release assay (IGRA) conversion among highly exposed TB contacts. We hypothesized that integration of...

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Topics

Humans
Tuberculin Test
Latent Tuberculosis
Interferon-gamma Release Tests
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mycobacterium tuberculosis

Male

Epigenesis, Genetic

Female

Monocytes

Adult

Multiomics

Source

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Identifiers

PMID: 40102730
DOI: 10.1186/s12864-025-11407-1
PMCID: PMC11916984

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