Back to search

Article

Multi-omic latent variable data integration reveals multicellular structure pathways associated with resistance to tuberculin skin test (TST)/interferon gamma release assay (IGRA) conversion in Uganda

2024-11-08

Abstract excerpt

Understanding the mechanisms of early clearance of Mycobacterium tuberculosis (Mtb) may illuminate new therapeutic strategies for tuberculosis (TB). We previously found genetic, epigenetic, and transcriptomic signatures associated with resistance (resister, RSTR) to tuberculin skin test (TST)/interferon gamma release assay (IGRA) conversion among highly exposed TB contacts. We hypothesized that integration of the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a3d0e07c-4a80-5309-ae82-bf6c6a7bba11
DOI
10.1101/2024.11.05.622020
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Multi-omic latent variable data integration reveals multicellular structure pathways associated with resistance to tuberculin skin test (TST)/interferon gamma release assay (IGRA) conversion in UgandaDOI 10.1101/2024.11.05.622020
Epigenetic programming of host lipid metabolism associates with resistance to TST/IGRA conversion after exposure to <i>Mycobacterium tuberculosis</i>Semantic proximity
<i>Mycobacterium tuberculosis</i>-dependent Monocyte Expression Quantitative Trait Loci and Tuberculosis PathogenesisSemantic proximity
Combining blood transcriptomic signatures improves the prediction of progression to tuberculosis among household contacts in BrazilSemantic proximity
DNA methylomes derived from alveolar macrophages and alveolar T cells display distinct patterns in tuberculosis – a future precision tool for TB status determination?Semantic proximity
Mycobacterium tuberculosis-dependent monocyte expression quantitative trait loci, cytokine production, and TB pathogenesisSemantic proximity
Identification of host gene expression biomarkers for tuberculosisSemantic proximity
Major Contribution of Myeloid Cells In TB specific Host Gene Signature: Revelations from Re-Analysis of Publicly Available DatasetsSemantic proximity
A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infectionSemantic proximity
Host transcriptional response to TB preventive therapy differentiates two sub-groups of IGRA-positive individualsSemantic proximity
Common gene signature model discovery and systematic validation for TB prognosis and response to treatmentSemantic proximity
A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection.Semantic proximity
Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitisSemantic proximity
Select a neighboring publication to make it the new centre.