Article

Epigenetic programming of host lipid metabolism associates with resistance to TST/IGRA conversion after exposure to <i>Mycobacterium tuberculosis</i>

2024-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Mycobacterium tuberculosis (Mtb) exposure leads to a range of outcomes including clearance, latent TB infection (LTBI), and pulmonary tuberculosis (TB). Some heavily exposed individuals resist tuberculin skin test (TST) and interferon gamma release assay (IGRA) conversion (RSTR), which suggests that they employ IFNγ-independent mechanisms of Mtb control. Here, we compare monocyte epigenetic prof...

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Literature Corpus work: 984e6a3a-fb00-5444-922a-4131d0949fa1
DOI: 10.1101/2024.02.27.582348

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