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Article

Differentially expressed transcript isoforms associate with resistance to tuberculin skin test and interferon gamma release assay conversion.

PloS one - 1 Jan 2023

Simmons Jason D, Segnitz R Max, Dill-McFarland Kimberly A, Stein Catherine M, Peterson Glenna J, Mayanja-Kizza Harriet, Boom W Henry, Hawn Thomas R

Abstract excerpt

BACKGROUND: A mechanistic understanding of uncommon immune outcomes such as resistance to infection has led to the development of novel therapies. Using gene level analytic methods, we previously found distinct monocyte transcriptional responses associated with resistance to Mycobacterium tuberculosis (Mtb) infection defined as persistently negative tuberculin skin test (TST) and interferon gamma release assay...

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Identifiers

PMID: 37058459
DOI: 10.1371/journal.pone.0284498
PMCID: PMC10104279

Genes

TST
ACSL4
GAPDH
PDE4A
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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