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Circulating metabolites associated with protection against Mycobacterium tuberculosis infection and inhibition of mycobacterial growth.

Communications biology - 21 May 2026

Setiabudiawan Todia P, Apriani Lika, Avila-Pacheco Julian, Ardiansyah Edwin, Kumar Vinod, Alisjahbana Bachti, Verrall Ayesha J, DiNardo Andrew R, Indrati Agnes R, Mourits Vera P, de Bree L Charlotte J, Moorlag Simone J C F M, Clish Clary B, Joosten Leo A B, van Laarhoven Arjan, van Meijgaarden Krista E, Netea Mihai G, Joosten Simone A, Koeken Valerie A C M, Hill Philip C, van Crevel Reinout

Abstract excerpt

A significant proportion of individuals who are heavily exposed to infectious tuberculosis patients do not acquire Mycobacterium tuberculosis (Mtb) infection, as detected by an interferon gamma release assay (IGRA). We examined circulating metabolite profiles and metabolic genotypes in 199 heavily exposed IGRA-negative tuberculosis household contacts in Indonesia. Based on differentially abundant metabolites,...

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PMID: 42162225
DOI: 10.1038/s42003-026-10241-9
PMCID: PMC13470225

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