Article
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank.
Communications biology - 8 Jun 2021
Valette Kim, Li Zhonglin, Bon-Baret Valentin, Chignon Arnaud, Bérubé Jean-Christophe, Eslami Aida, Lamothe Jennifer, Gaudreault Nathalie, Joubert Philippe, Obeidat Ma'en, van den Berge Maarten, Timens Wim, Sin Don D, Nickle David C, Hao Ke, Labbé Catherine, Godbout Krystelle, Côté Andréanne, Laviolette Michel, Boulet Louis-Philippe, Mathieu Patrick, Thériault Sébastien, Bossé Yohan
Abstract excerpt
To identify candidate causal genes of asthma, we performed a genome-wide association study (GWAS) in UK Biobank on a broad asthma definition (n = 56,167 asthma cases and 352,255 controls). We then carried out functional mapping through transcriptome-wide association studies (TWAS) and Mendelian randomization in lung (n = 1,038) and blood (n = 31,684) tissues. The GWAS reveals 72 asthma-associated loci from 116...
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