Article
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.
Nature communications - 15 Apr 2020
Han Yi, Jia Qiong, Jahani Pedram Shafiei, Hurrell Benjamin P, Pan Calvin, Huang Pin, Gukasyan Janet, Woodward Nicholas C, Eskin Eleazar, Gilliland Frank D, Akbari Omid, Hartiala Jaana A, Allayee Hooman
Abstract excerpt
Asthma is a chronic and genetically complex respiratory disease that affects over 300 million people worldwide. Here, we report a genome-wide analysis for asthma using data from the UK Biobank and the Trans-National Asthma Genetic Consortium. We identify 66 previously unknown asthma loci and demonstrate that the susceptibility alleles in these regions are, either individually or as a function of cumulative...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.