Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pro-fibrotic phenotype of bone marrow stromal cells in Modic type 1 changes.

European cells & materials - 8 Jun 2021

Heggli I, Epprecht S, Juengel A, Schuepbach R, Farshad-Amacker N, German C, Mengis T, Herger N, Straumann L, Baumgartner S, Betz M, Spirig J M, Wanivenhaus F, Ulrich N, Bellut D, Brunner F, Farshad M, Distler O, Dudli S

Abstract excerpt

Modic type 1 changes (MC1) are painful vertebral bone marrow lesions frequently found in patients suffering from chronic low-back pain. Marrow fibrosis is a hallmark of MC1. Bone marrow stromal cells (BMSCs) are key players in other fibrotic bone marrow pathologies, yet their role in MC1 is unknown. The present study aimed to characterise MC1 BMSCs and hypothesised a pro-fibrotic role of BMSCs in MC1. BMSCs were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Extracellular Matrix

Share to Fibrosis

Share to Mesenchymal Stem Cells

Share to Myofibroblasts

Share to Signal Transduction

Source

Identifiers

PMID: 34101158
DOI: 10.22203/eCM.v041a42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pro-fibrotic phenotype of bone marrow stromal cells in Modic type 1 changes.PMID 34101158Read ↗

Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapiesSemantic proximity Read ↗

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis.Semantic proximity Read ↗

Bone marrow fibrosis with fibrocytic and immunoregulatory responses induced by β-catenin activation in osteoprogenitors.Semantic proximity Read ↗

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cellsSemantic proximity Read ↗

Recapitulation of pro-inflammatory signature of monocytes with ACVR1 mutation using FOP patient-derived iPSCs.Semantic proximity Read ↗

Intradiscal propionic acid levels in chronic low back pain patients with Modic type 1 changes are associated with systemic immune cell activationSemantic proximity Read ↗

Blood immune profiles in chronic low back pain patients with type 1 Modic changes are associated with intradiscal propionic acid levelsSemantic proximity Read ↗

Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs.Semantic proximity Read ↗

Leptin-receptor-expressing bone marrow stromal cells are myofibroblasts in primary myelofibrosis.Semantic proximity Read ↗

Extracellular matrices of bone marrow stroma regulate cell phenotype and contribute to distinct stromal niches <i>in vivo</i>Semantic proximity Read ↗

A Whole Exome Study Identifies Novel Candidate Genes for Vertebral Bone Marrow Signal Changes (Modic Changes).Semantic proximity Read ↗

Extracellular matrices of stromal cell subtypes regulate phenotype and contribute to the stromal microenvironment in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.