Article

Blood immune profiles in chronic low back pain patients with type 1 Modic changes are associated with intradiscal propionic acid levels

2026-08-03

Abstract excerpt

<title>Abstract</title> <p> Background Modic type 1 changes (MC1) are vertebral endplate bone marrow lesions associated with chronic low back pain (CLBP), but their underlying pathobiology remains unclear. Disc–bone marrow crosstalk that includes <italic>Cutibacterium acnes (C. acnes)</italic> infection of the disc and immune system activation in the adjacent vertebrae may be a defining feature of some MC1. M...

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Literature Corpus work: a55be52e-e2a8-5400-84f0-bd0b81f36fab
DOI: 10.21203/rs.3.rs-10508730/v1

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