Article
Extracellular matrices of stromal cell subtypes regulate phenotype and contribute to the stromal microenvironment in vivo.
Stem cell research & therapy - 18 Jun 2024
Stone Andrew P, Rand Emma, Thornes Gabriel, Kay Alasdair G, Barnes Amanda L, Hitchcock Ian S, Genever Paul G
Abstract excerpt
BACKGROUND: Bone marrow stromal cells (BMSCs) are highly heterogeneous, which may reflect their diverse biological functions, including tissue maintenance, haematopoietic support and immune control. The current understanding of the mechanisms that drive the onset and resolution of heterogeneity, and how BMSCs influence other cells in their environment is limited. Here, we determined how the secretome and...
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