Article

Intradiscal propionic acid levels in chronic low back pain patients with Modic type 1 changes are associated with systemic immune cell activation

2026-01-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Modic type 1 changes (MC1) are vertebral endplate bone marrow lesions strongly associated with chronic low back pain (CLBP), but their underlying pathobiology remains unclear. Recent findings suggest that disc–bone marrow crosstalk that includes Cutibacterium acnes (C. acnes) infection of the disc, and immune system activation in the adjacent vertebrae may play a significan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 499bebab-dbfe-5fe7-8c37-c4445fac8d0a
DOI: 10.64898/2026.01.06.26343445

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intradiscal propionic acid levels in chronic low back pain patients with Modic type 1 changes are associated with systemic immune cell activationDOI 10.64898/2026.01.06.26343445Read

Blood immune profiles in chronic low back pain patients with type 1 Modic changes are associated with intradiscal propionic acid levelsSemantic proximity Read

HLA-A*26:01 is associated with vertebral endplate bone marrow lesions (Modic changes) in chronic low back pain: a novel immune-genetic linkSemantic proximity Read

New Insights Link Low-Virulent Disc Infections to the Etiology of Severe Disc Degeneration and Modic ChangesSemantic proximity Read

Modic changes are associated with activation of intense inflammatory and host defense response pathways – molecular insights from proteomic analysis of human intervertebral discsSemantic proximity Read

Protocol for Biospecimen Collection and Analysis Within the BACPAC Research Program.Semantic proximity Read

Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvementSemantic proximity Read

Colonization of intervertebral discs by<i>Cutibacterium acnes</i>in patients with low back pain: protocol for an analytical study with microbiological, phenotypic, genotypic, and multiomic techniquesSemantic proximity Read

Human intervertebral discs harbour a unique microbiome and dysbiosis determines health and diseaseSemantic proximity Read

Pro-fibrotic phenotype of bone marrow stromal cells in Modic type 1 changes.Semantic proximity Read

Modic changes and its association with other MRI phenotypes in east Anatolian low back pain patients.Semantic proximity Read

Refined Phenotyping of Modic Changes: Imaging Biomarkers of Prolonged Severe Low Back Pain and Disability.Semantic proximity Read

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J miceSemantic proximity Read