Article

Recapitulation of pro-inflammatory signature of monocytes with ACVR1 mutation using FOP patient-derived iPSCs.

2022-05-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive heterotopic ossification (HO) in soft tissues due to a heterozygous mutation of the ACVR1A/ALK2 gene (FOP-ACVR1A), which erroneously transduces the BMP signal by Activin-A. Although inflammation is known to trigger HO in FOP, the role of FOP-ACVR1A on inflammatory c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 722736b0-f8d0-532b-b8ec-a5272fa8713d
DOI: 10.21203/rs.3.rs-1544500/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recapitulation of pro-inflammatory signature of monocytes with ACVR1 mutation using FOP patient-derived iPSCs.DOI 10.21203/rs.3.rs-1544500/v1Read

Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs.Semantic proximity Read

NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossificationSemantic proximity Read

Depletion of Mast Cells and Macrophages Impairs Heterotopic Ossification in an Acvr1R206H Mouse Model of Fibrodysplasia Ossificans Progressiva.Semantic proximity Read

Transcriptomic Differences Underlying the Activin-A Induced Large Osteoclast Formation in Both Healthy Control and Fibrodysplasia Ossificans Progressiva Osteoclasts.Semantic proximity Read

Fibrodysplasia ossificans progressiva: a blueprint for metamorphosisSemantic proximity Read

Fibrodysplasia ossificans progressiva emerges from obscurity.Semantic proximity Read

ACVR1R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophagesSemantic proximity Read

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressivaSemantic proximity Read

iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva.Semantic proximity Read

New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans ProgressivaSemantic proximity Read

Over-expression of wild-type <i>ACVR1</i> in fibrodysplasia ossificans progressiva mice rescues perinatal lethality and inhibits heterotopic ossificationSemantic proximity Read

Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans Progressiva Mice Rescues Perinatal Lethality and Inhibits Heterotopic Ossification.Semantic proximity Read