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Article

Bone marrow fibrosis with fibrocytic and immunoregulatory responses induced by β-catenin activation in osteoprogenitors.

Bone - 1 Mar 2016

Yu Jian, Cao Jingjing, Li Hanjun, Liu Pei, Xu Shuqin, Zhou Rujiang, Yao Zhengju, Guo Xizhi

Abstract excerpt

Wnt/β-catenin signaling has been reported to contribute to the development of bone fibrous dysplasia. However, it remains unclear whether fibrocytes and immune cells are involved in this β-catenin-mediated bone marrow fibrosis. In this study, we showed that constitutive activation of β-catenin by Col1a1-Cre (3.6-kb) exhibited bone marrow fibrosis, featured with expanded populations of fibrocytes, myofibroblasts...

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Identifiers

PMID: 26688275
DOI: 10.1016/j.bone.2015.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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